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The term "vestibular suppressant" is a vague one generally used to indicate drugs that reduce nystagmus evoked by a vestibular imbalance or which reduce motion sickness.Table 1 lists commonly used vestibular suppressants, which consist of three major drug groups, the anticholinergics, the antihistamines, and the benzodiazepines.

Stimulation of the two types of GABA receptors, GABA-A and GABA-B, have similar effects on vestibular pathways (Neerven et al, 1989), but specific GABA-B agonists, such as baclofen, decrease the duration of vestibular responses in animal models (Cohen et al, 1987).Histamine (H1-H3) is found diffusely in central vestibular structures and centrally acting antihistamines modulate symptoms of motion sickness (Takeda et al, 1989).Both the H1 and H2 subtypes of histamine receptors affect vestibular responses (Serafin et al, 1992).However there are also nicotinic receptors, as well as M1 and M5 (Soto et al, 2013).In the CNS, the N or P/Q type are the ones that participate in neurotransmitter release.

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